Clinicopathological and Immunopathological Profile of Membranous Nephropathy: A Single-Center Study

Muzamil A Wani; Muzaffar Wani; Imtiyaz A Wani; Rayees Yousf; Manzoor A Parry

doi:10.33883/jms.v28i4.1464

Muzamil A Wani
Muzaffar Wani Department of Nephrology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar
Imtiyaz A Wani Department of Nephrology, SKIMS
Rayees Yousf Department of Nephrology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar
Manzoor A Parry Department of Nephrology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar

DOI: https://doi.org/10.33883/jms.v28i4.1464

Abstract

Introduction

Primary membranous nephropathy (PMN) is a specific pathological disorder of the glomerulus characterized by thickening of the capillary glomerular wall due to subepithelial immune complex deposition where a secondary cause of glomerular lesion is excluded¹

It is one of the most common causes of nephrotic syndrome in adult non-diabetic patients. Around 30% of cases of adult nephrotic syndrome are due to membranous nephropathy only surpassed by non-diabetic podocytopathy with focal segmental glomerulosclerosis lesions in African and Hispanic Americans.² 70% of PMN have circulating IgG4 autoantibody to podocyte membrane antigen phospholipase A2 receptor (PLA2R)¹